The Prince is located at the top of Karazhan and proves to be a very hard fight throughout its 3 stages. He summons Infernals from the sky, Axes to aid him, and deals heavy melee damage. The raid positioning is key for this fight, but once everybody know where to be (and even more where NOT to be) it becomes a still hard but enjoyable fight.

Maiden of Virtue is a tough boss with both Paladin and Priest abilities. She can deal lots of damage to everyone around her so your raid’s healing and dispelling has to be very responsive.

Easiest way is to have a paladin using Blessing of Sacrifice on the tank before Repentance hits. When they damage for the blessing, the incapacitation is removed. The other option is to have one healer stand in the holly ground. The damage taken from the holy ground breaks the repentance. Point is, one healer should be able to heal the tank while everybody else is incapacitated.

Moroes is an undead Rogue boss found in the Dining Hall of Karazhan, who has four undead adds with him.

He can be a challenging fight because his Garrote ability deals significant damage over a long period of time.
Make sure you have a paladin with you, that will help.

The Shade of Aran is one of the hardest and enjoyable Boss in Karazhan.
He has a lot of abilities to counter and it requires a great deal of execution by the raid to get him down.
Located in the Guardian's Library, with one door that closes and locks as soon as the fight begins, you have no way out...

Even though The Shade of Aran is an optional boss, defeating him is very helpful as a teleport to his room becomes available from Berthold , and cancels all mobs respawn from the Curator to Aran .

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Netherspite is one of the optional boss in Karazhan.

He will require specific attention though.
Your raid needs to be perfectly organized and will have to respect a very sharp timing.
Perfect concentration and coordination will be key in your success in this challenge.

Attumen the Huntsman is the first boss in Karazhan, he's usually used as a "check text" to see if the raid has the right level to go further.

Midnight, his mount,is at 95% health.